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These include: Personal or family history of medullary thyroid carcinoma Personal history of Multiple Endocrine Neoplasia syndrome type 2 (MEN 2) Active or recent history of pancreatitis Pregnancy or planning to become pregnant Breastfeeding individuals Severe gastrointestinal disease or gastroparesis Patients with any of these conditions are advised against using GLP-1 medications, including compounded semaglutide, due to elevated risks identified in clinical studies

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HbA1c was also used to determine glycaemic category (normoglycaemia, prediabetes or diabetes, as per American Diabetes Association HbA1c criteria 21 ) and changes in the proportion of participants in each category were assessed

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Tirzepatide works by activating GIP and GLP-1 receptors, two natural pathways involved in appetite regulation and metabolism

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