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One possible explanation for the similar effects on weight loss observed with both GIPR agonism and antagonism might be that chronic pharmacological GIPR activation induces functional antagonism in a subset of neurons through receptor desensitization, as seen in adipocytes, isolated pancreatic islets and mouse neuroblastoma Neuro2a cells 36,37
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Phase 5: maintenance (week 13 and beyond) Concentration: 3mg/mL suspension
[DOI] [PubMed] [Google Scholar] 5.Mind-wandering: phenomenology and function as assessed with a novel experience sampling method
[DOI] [PubMed] [Google Scholar] 177
