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"Key interactions by conserved polar amino acids located at the transmembrane helical boundaries in Class B GPCRs modulate activation, effector specificity and biased signalling in the glucagon-like peptide-1 receptor"
This prevents blood sugar from spiking after a meal

[DOI] [PMC free article] [PubMed] [Google Scholar] 4.Gonzlez-Muniesa P, Mrtinez-Gonzlez MA, Hu FB, Desprs JP, Matsuzawa Y, Loos RJ, Moreno LA, Bray GA, Martinez JA
Although some studies have raised concerns about pancreatitis and thyroid-related risks, the current evidence does not conclusively establish causality
