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Data Availability Statement There are no data underlying this work.

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When considering current recommendations from the ADA for add-on therapy to metformin in patients not achieving individualized glycemic goals, PIONEER 2 provides valuable data comparing the addition of either an oral GLP-1 receptor agonist or an SGLT-2 inhibitor

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Another MRI study suggested it reduces tongue fat deposition, which correlates with changes in weight and waist circumference