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Stigma surrounding GLP-1 weight loss treatments reveals societal biases, impacting individuals' mental health and the effectiveness of obesity interventions.

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It details preclinical and clinical evidence linking GLP-1 receptor activation to cardiovascular, renal, hepatic, neural, and joint anti-inflammatory effects while outlining uncertainties and future research needs.

As doctors learn why GLP-1s don't work for about 50% of people, they are also learning more about the complex drivers of obesity

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