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Alternative Treatments for IBS in the UK NICE recommends a stepwise approach to IBS management , beginning with lifestyle modifications and progressing to pharmacological interventions based on symptom severity and predominant subtype

The downstream healthcare savings from better obesity control, including reduced diabetes, cardiovascular disease, and joint replacement costs, could offset medication expenses for both patients and the healthcare system

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The Negatives: What the Trials Showed Across programs like STEP, SURMOUNT, and SELECT, side effects were largely gastrointestinal: Nausea, vomiting, constipation, diarrhea

It is noteworthy that this superior effectiveness extended to primates (humans and cynomolgus monkeys) and rodent models of obesity and diabetes, such as db/db (diabetic) mice and Zucker diabetic fatty (ZDF) rat