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Therefore, almost all scientific guidelines now recommend specific treatments for patients with type 2 diabetes based on CVOTs data, namely adding to metformin a SGLT-2 inhibitor or a GLP-1RA with proven CV disease benefit in patients with type 2 diabetes and CV disease, established kidney disease, or HF [7,8,9,10]

And some never achieve consistent enough absorption for meaningful results

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This 12-year period has been the subject of repeated legislative proposals to shorten it, most recently in the context of the Inflation Reduction Act, but as of early 2026 it remains intact

It is specifically valuable as a sign of disease among patients who are characterised as overweight or obese [Figure 1]