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Novartis supported the expansion application with topline data from the Phase III NATALEE trial, in which treatment with Kisqali led to a significant improvement in disease-free survival versus standard adjuvant endocrine therapy alone, according to the company

Lastly, the experimental conditions that lead to the increase in glucagon and glucagon action on the GLP-1r were specific to having both elevations in glucose and amino acids

Side effects are uncommon, but they may include headaches, nausea, vomiting, diarrhea, constipation and gas

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