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3 Safety & Tolerability Under the Microscope Injection-site reactions were notable: 12% with CagriSema 17% with cagrilintide alone 2.6% with semaglutide alone While overall discontinuation remained low (~1%), tolerability will be a key differentiator versus Lillys portfolio

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For Ozempic, doses up to 2.0 mg weekly are FDA-approved for diabetes

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Following a single oral 100 mg dose to healthy volunteers, mean plasma AUC of sitagliptin was 8.52 Mhr, Cmax was 950 nM, and apparent terminal half-life (t1/2) was 12.4 hours