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In a double-blind, randomized trial of 44 metformin-treated patients with T2DM, neither dapagliflozin nor gliclazide significantly altered gut microbiome composition over 12 weeks, despite exhibiting divergent metabolic effects such as reduced weight and fasting insulin with dapagliflozin and increased insulin with gliclazide [40]

Krassowska A, Ten Wolde H

Less likely to have a stroke, less likely to get diabetesand colorectal cancer, less likely to die from cancer across the board, and less likely to die from all causes put together

Safety and efficacy of oral semaglutide versus dulaglutide in Japanese patients with type 2 diabetes (PIONEER 10): a multicentre, open-label, randomised, phase 3a trial

Scientists are working on solutions to these side effects