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Through coordinated activation of incretin and glucagon pathways, retatrutide enhances glucose-dependent insulin secretion, improves glycemic control, promotes lipid utilization and energy expenditure, and reduces appetite and food intake, highlighting its relevance for obesity and type 2 diabetes [2,3]
Notably, genome-wide association study (GWAS) analyses for body mass index (BMI) have linked glutamatergic signalling and NMDA receptor-related neuroplasticity to regulation of body weight and obesity 1,5
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