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Whether this is a direct action of metformin on GLP-1 release, and whether some of the glucose-lowering effect of metformin occurs due to GLP-1 release, is unknown

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Martnez-Herrera B-E, Muoz-Garca M-G, Jos-Ochoa L-L, Quiroga-Morales L-A, Cervntes-Gonzlez L-M, Mireles-Ramrez M-A, et al

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Due to the rapid enzymatic degradation and short half-life of native GLP-1, structurally modified analogs such as liraglutide have been developed for extended stability in controlled research environments

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Depending on the exact brand name drug, GLP-1s are FDA-approved to help manage type 2 diabetes, to facilitate weight management, or to help with both

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GLP-1 Receptor Agonists -Cell Function The anti-hyperglycemic benefits attributable to GLP-1RA-based therapy are primarily due to their direct action on pancreatic -cells

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