side effects of glp-1 receptor agonists Comparison adverse between Gastrointestinal effect and adverse effects

20 years of post-marketing safety experience

Zhang Y, Qu Z, Lu T, Shao X, Cai M, Dilimulati D, Gao X, Mao W, Hu F, Su L, Liao Q, Han T, Zhang M, Qu S

Compared with the HF group, the HF+Lira group decreased serum AST, ALT, and TC, serum TG levels decreased significantly, the mRNA expression of SOCS-3 and SREBP-1c decreased significantly, and the liver TG level was also reduced

In the DURATION-8 trial, patients treated with exenatide ER plus dapagliflozin achieved nearly double the weight reduction observed with each monotherapy, with numerically larger effects in individuals with higher baseline BMI

cohort study, the 2-year discontinuation rate for GLP-1 receptor agonists was 64.1% among people with type 2 diabetes mellitus, driven by factors such as older age, low income, gastrointestinal adverse events, and insufficient weight loss [115]