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Another successful GLP-1 RA, lixisenatide, was launched in the U.S

However, these over-the-counter products are not FDA-approved medications and contain no actual GLP-1 receptor agonists

doi: 10.1016/0140-6736(92)92814-v 24 BugianesiEMoscatielloSCiaravellaMFMarchesiniG

Although a fairly large proportion of patients have reported a number of side effects, particularly at the gastrointestinal level (nausea, vomiting, diarrhoea), these side effects tend to diminish over time and adherence to treatment remains high, with about 5% of patients discontinuing treatment due to side effects

The Price: What If the Bill Comes Later