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Some women may experience increased vaginal dryness as a result. She continued, Additionally, GLP-1 agonists can cause gastrointestinal side effects like nausea, vomiting, and diarrhoea

J., Coghlan, M

According to the UK SmPC, the most common side effects include: Nausea (1222% of patients, dose-dependent) Diarrhoea (1216%) Vomiting (610%) Decreased appetite (59%) Constipation (67%) These effects are typically mild to moderate, occurring predominantly during dose escalation, and diminish over 48 weeks

It is likely that the gastrointestinal adverse effects of GLP-1 RAs can contribute to the development of CI by the induction of constipation and volume depletion, the latter of which can result in systemic hypotension which is a known risk factor of CI

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