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It is therefore the synergistic actions of GLP-1 in the gut and brain, acting on both central and peripheral receptors that seem responsible for the effects of the hormone on satiety

Its ability to reduce weight significantly and improve metabolic health makes it a breakthrough therapy
Gastroparesis is defined by abnormally delayed gastric emptying in the absence of mechanical obstruction

Finally, for T2DM patients with additional risk factors for PsA (eg, family history, personal history of psoriasis, enthesitis symptoms), SGLT2i may be preferred over GLP-1 RA, pending confirmation in randomized trials

Semaglutide and Tirzepatide are medications used for weight loss
