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Description
MG treatment induced apoptosis of beta cells, impaired mitochondrial function, and prolonged activation of AMP-dependent protein kinase (AMPK)
Also known as GLP-1 medications, these popular drugs were initially approved to treat type 2 diabetes, but doctors quickly discovered that they also facilitated significant weight loss thus, the birth of the weight-loss drug craze.
(For a detailed history, I recommend Megan Molteni and Elaine Chens piece for STAT.) The benefits of these drugs are undeniable, but when it comes to evaluating their risks, we run into challenges that researchers are familiar with but that the public at large may not be aware of
Recent research has found that the use of GLP-1 receptor agonists such as Ozempic during pregnancy is no more likely to lead to congenital malformations in infants than insulin use.
Recent studies indicate that glucagon-like peptide (GLP)-1 inhibits appetite in part through regulation of soluble leptin receptors
