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Science 315 , 18171822 (2007)

Starting low dose and going slow really helps with that
By increasing BDNF expression, rapamycin may support neuronal growth and synaptic connectivity, helping to reverse the structural and functional brain changes associated with mood disorders (105)

And as recently as April, industry giant Pfizer halted its development of a GLP-1 competitor following reports of drug-induced liver injury
