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Metabolic health profile

GLP-1 medications such as semaglutide (Ozempic, Wegovy), liraglutide (Victoza, Saxenda), and dulaglutide (Trulicity) are prescribed in the UK for type 2 diabetes or weight management under NICE guidance

demonstrated that bromocriptine improves glucose metabolism in prolactin-deficient, MC4R-deficient, and circadian disrupted mice (88) indicating that the glucose-lowering effect is independent of prolactin, MC4R, or circadian rhythms

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Excess macronutrients in adipose tissues trigger the release of inflammatory mediators, including leptin, tumor necrosis factor-, and interleukin-6, while decreasing the production of adiponectin (an anti-inflammatory adipokine), predisposing to a pro-inflammatory state and oxidative stress