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Excess adiposity, particularly visceral fat, is associated with metabolic dysfunction that may affect hormone regulation

17 Moreover, by interacting with ligands such as ADA, DPP4 exerts noncatalytic functions, including co-stimulating T-cell activation and promoting lymphocyte proliferation, which can be beneficial in modulating immune responses

A health care provider should help patients determine if these medications are appropriate for them

Bottom Line on Effectiveness: Tirzepatide Alternatives: Mounjaro, Zepbound, and properly compounded tirzepatide all produce 15-22% average weight loss Choose based on cost, availability, and conveniencenot effectiveness concerns Semaglutide Alternatives: Wegovy, Ozempic, and properly compounded semaglutide all produce 10-15% average weight loss Slightly less potent than tirzepatide but still highly effective Best value for weight loss medication The active ingredient determines effectiveness, not the brand name on the label

doi: 10.1210/jcem-63-2-492 28 NauckMStckmannFEbertRCreutzfeldtW