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In: Diabetes UK [Internet]

Entry Version: Citation: Pancreapedia: Exocrine Pancreas Knowledge Base , DOI: 10.3998/panc.2021.06 Abstract: Glucagon like peptide-1 (GLP-1) is a GI hormone produced in endocrine cells in the distal small intestine by alternative processing of the proglucagon gene product

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Sulfonylurea compounds uncouple the glucose dependence of the insulinotropic effect of glucagon-like peptide 1

This leads to: Excessive muscle loss Fatigue and weakness Hair thinning or shedding (telogen effluvium) Nutrient deficiencies Metabolic slowdown How to prevent this: Track protein intake (minimum 0.7g per pound of body weight daily) Eat protein first at every meal Use protein shakes if whole food feels too filling Dont let the medication be an excuse to skip meals Dehydration: Reduced food intake often means reduced fluid intake