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Structural insights into the triple agonism at GLP-1R, GIPR and GCGR manifested by retatrutide

In this Review, the authors discuss the potential effects of GLP-1 receptor agonists on the incidence, disease activity and progression of various forms of arthritis, as well as practical considerations for their use in this context.

Smaller meals, hydration, slower dose increases, and better timing can often reduce it.

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