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Although the serotonergic pathway may create a physiological decrease in sexual desire for patients taking GLP-1 agonists, we postulate that this diminishing influence of GLP-1 agonism is both compounded by factors such as undesirable side effects and increased SHBG and offset by the enhancing influences on sexual desire such as increased total testosterone, and improved vascular reactivity and mood

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Despite the high cost of GLP-1 RAs, our findings further showed that nationwide only less than 5% of the drug cost of GLP-1 RAs was paid by the patient, and more than 95% was paid by insurance

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That makes it safer from a medical standpoint, but it also limits flexibility and may cause longer wait times during national shortages