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With the ageing of society, stroke has emerged as the leading cause of mortality and major cause of disability worldwide, greatly increasing the burden of human society (46)

Calcium (1,000 to 1,200 mg daily) and Vitamin D3 (1,500 to 2,000 IU daily)

But it wasn't until recently that GLP-1 RAs entered the mainstream, with the approval of semaglutide injections for weight loss and the publication of a key research study showing that weekly injections of semaglutide caused an average 15% loss of body weight in participants

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For instance, large-scale trials of modern GLP-1RAs began over a decade ago and have enrolled over 70,000 patients collectively, with some individual trials following patients for 5-7 years