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Eli Lilly has disclosed the structure of its next-generation small molecule GLP-1R agonist, naperiglipron (LY3549492), at a pivotal moment for the class

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Reducing the risk of major cardiovascular events (like heart attacks or strokes) in people with type 2 diabetes and heart disease

Ozempic is indicated as an adjunct to diet and exercise to improve glycemic control in adult patients with type 2 diabetes and to reduce the risk of major adverse cardiovascular (CV) events (CV death, nonfatal myocardial infarction, or nonfatal stroke) in adults with type 2 diabetes mellitus and established CV disease

last year in a deal valued at up to $2B, including $80M upfront