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liraglutide significantly decreased body fat and waist-to-hip ratio (p=0.003), and exenatide reduced waist-to-hip ratio but had minimal weight loss benefits.[6] In the STEP1 study, adults with obesity without diabetes receiving semaglutide 2.4mg plus lifestyle interventions had a mean weight loss of 14.9% from baseline in addition to improved fasting glucose and lipids, increased physical activity, and decreased fat mass.[7] The SURMOUNT-1 trial demonstrated that tirzepatide 5mg, 10mg, and 15mg caused significant improvement in weight, total body fat mass, lipids, systolic and diastolic blood pressure, and fasting insulin levels.[5] Cardiovascular disease risk reduction Diabetes represents a major risk factor for cardiovascular disease

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