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A recent meta-analysis of randomized controlled trials (RCTs), including AMPLITUDE-O, examining six GLP-1 receptor agonists (lixisenatide, liraglutide, subcutaneous semaglutide, exenatide, dulaglutide, and efpeglenatide) reported a 21% reduction in a composite kidney outcome (macroalbuminuria, doubling of serum creatinine or 40% eGFR decline, RRT, or death from kidney disease), corresponding to a number needed to treat of 47 [73]

[DOI] [PMC free article] [PubMed] [Google Scholar] 42.Karhunen V., Daghlas I., Zuber V., Vujkovic M., Olsen A.K., Knudsen L.B., Haynes W.G., Howson J.M.M., Gill D

In 2022, approximately 43% of adults were overweight, and 16% were classified as obese, representing nearly 890 million people worldwide, with rates having more than doubled since 1990

Concerning long-term outcomes, extended AOM usage substantially enhanced results, as patients maintaining medication consistently demonstrated 14.70%-17.34% weight reduction versus merely 9.25%-12.56% with short-duration use