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GLP-1RA can enhance renal function and renal blood flow, facilitate the recovery of vascular endothelial function, reduce urinary protein, and play a protective role in the kidney

it can centrally inhibit bone formation by binding to leptin receptors in the hypothalamus or locally promote bone formation and inhibit bone resorption by binding to receptors expressed on the surface of osteoblasts [100]

While individual experiences vary widely, certain patterns emerge from the thousands of people who have made this switch

Not gradually