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Pro-GIP comprises 144 (rodent) or 153 (human) amino acids and harbors the GIP sequence flanked by N- and C-terminal peptide sequences [86,[217], [218], [219], [220], [221], [222]]

Like Semaglutide, it acts on GLP-1 receptors, but it also targets GIP (glucose-dependent insulinotropic polypeptide) receptors

A typical approach might begin with Retatrutide alone for 4 to 8 weeks, add BPC-157 during dose escalation when GI symptoms peak, introduce TB-500 after reaching maintenance Retatrutide doses, and finally add GHK-Cu when significant weight loss begins affecting skin appearance

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Detectable weight loss typically begins between weeks 4 and 8 of starting oral semaglutide, though some patients see changes by week 2-3