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Patients with disc-at-risk anatomy display these characteristic features: Small optic disc diameter (less than 1.2 millimeters) Minimal or absent physiological cup (cup-to-disc ratio of 0.2 or less) Crowded arrangement of approximately 1.2 million nerve fibers Limited space for axons to exit through the lamina cribrosa Increased susceptibility to compartment syndrome effects The pathophysiological mechanism underlying NAION involves a cascade of events beginning with initial hypoperfusion of the optic nerve head

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Although more human trials are needed it provides important information about posology, route administration, and possible adverse effects [98]

10.1007/s11695-023-06863-1 [DOI] [PubMed] [Google Scholar] 68.Van Beek A, Emous M, Laville M, Tack J