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Description
Targeting GLP-1R expressed on microglia by NLY01 selectively inhibits microglial activation and induction of the reactive astrocyte inducers TNF-, C1q, and IL-1, thus protecting both mouse (5xFAD and 3xTg-AD mice) and human neurons in vitro (human embryonic stem cell (hESC)-derived human cortical neurons) [159]
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Sci Adv 2024;10:eado1820.ArticlePubMedPMC 52
Ex vivo pancreatic islet GSIS assay Pancreatic islets were isolated from WT or GLP-1R knockout C57BL/6 mice 99 using collagenase perfusion 78
