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Each new celebrity ambassador fuels the perception that these drugs are not only effective but aspirational a modern wellness rite of passage rather than a tightly controlled prescription therapy

Patients experiencing hair thinning should be encouraged to discuss their concerns with their GP or prescribing clinician rather than discontinuing treatment abruptly, as the underlying condition being treated (diabetes or obesity) requires ongoing management

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In conclusion, our study provides valuable structural insights into the mechanism underlying the superior clinical efficacy of retatrutide, a unimolecular triple agonist simultaneously activating GLP-1R, GIPR and GCGR