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In HF with preserved ejection fraction and mildly reduced ejection fraction, semaglutide improved symptoms, physical function, natriuretic peptide levels, echocardiographic parameters, and HF hospitalizations, as shown in the STEP-HFpEF program and a pooled analysis of trials

| Sarah Jones Simmer, CEO of Found, said that the trends are likely the result of irresponsible prescribing for recreational reasons causing the pendulum to swing "all the way in the other direction," and it's leading to patients who have genuine medical need struggling to access these therapies.

Microdose semaglutide represents a lower-entry approach to GLP-1 weight loss therapy, allowing patients to start treatment gradually while minimizing side effects

Initial treatment withacetazolamide was discontinued due to intolerance.Exenatide was subsequently initiated, leading to early improvement in headache frequency and diplopia, independent of weight loss

There are still substantial clinical challenges in treating patients who come with type 2 diabetes and/or obesity in addition to chronic kidney disease (CKD)