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While an occasional protein shake is fine, replacing all meals with liquid calories often leads to blood sugar instability (liquid calories absorb faster) and inadequate satiety (chewing and the act of eating contribute to feeling satisfied)

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Administration technique (hold time, any issues)

In a post hoc analysis, presented at ESC 2025 and including ~750 participants who completed 72 weeks of treatment, 10year cardiovascular disease (CVD) risk was estimated using validated BMIbased Framingham equations

At the same time, preserving lean muscle mass during rapid weight loss remains important