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Abbreviations PCOS: Polycystic ovary syndrome MET: Metformin COM: Metformin combined with semaglutide therapy CRP: C-reactive protein WHR: Waist-to-hip ratio UA: Uric acid ALT: Alanine aminotransferase AST: Aspartate aminotransferase TG: Triglycerides TC: Total cholesterol HDL-C: High-density lipoprotein cholesterol LDL-C: Low-density lipoprotein cholesterol WBCs: White blood cells CRP: C reactive protein HbA1c: Glycosylated hemoglobin FBG: Fasting blood glucose FINS: Fasting insulin HOMA-IR: Homeostasis model assessment of insulin resistance SHBG: Sex hormone binding globulin DHEA-S: Dehydroepiandrosterone sulfate E2: Estradiol TEST: Testosterone PRL: Prolactin FAI: Free androgen index LH: Luteinizing hormone FSH: Follicle stimulating hormone AMH: Anti-Mllerian hormone CVAI: Chinese visceral adiposity index hCG: Human chorionic gonadotrophin CV: Coefficients of variation ELISA: Enzyme-linked immunosorbent assay GLP-1 RAs: Glucagon-like peptide-1 receptor agonists WC: Waist circumference HC: Hip circumference HPO: Hypothalamicpituitaryovarian SD: standard deviation References Stener-Victorin E, Teede H, Norman RJ, Legro R, Goodarzi MO, Dokras A, Laven J, Hoeger K, Piltonen TT

Early weeks, dose changes, water shifts, appetite, nutrition, activity, and health history all matter

But on GLP-1 medications, the standard advice of just eat more fiber ignores a fundamental problem

Instead, the new information highlights the importance of good nutrition (including plenty of bone-supporting calcium and vitamin D), strength training, and monitoring bone health during significant weight loss

If you accidentally freeze your semaglutide, do not use itfreezing damages the peptide structure and renders the medication less effective