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The commercial logic is standard lifecycle management: create a clinically differentiated successor product, build a new patent estate around it, transition prescribers before the original goes off-patent, then allow the original to be commoditized by biosimilars while defending revenue in the new protected formulation

Insulin sensitivity and glucose regulation also shift after Ozempic cessation

While berberine shows some hepatoprotective effects in certain contexts, it also undergoes extensive liver metabolism

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