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The SELECT trial, which evaluated semaglutide 2.4 mg against placebo for cardiovascular outcomes in patients with overweight and obesity without type 2 diabetes, showed significant decreases in total cholesterol, LDL-C, and triglycerides and an increase in HDL-C at 39.8 months [48]

doi: 10.1111/obr.12467 [DOI] [PubMed] [Google Scholar] 18.Wijma RB, Emous M, van den Broek M, Laskewitz A, Kobold ACM, van Beek AP

This distinction matters enormously when evaluating tirzepatide risk because the FDA warning specifically concerns C-cell tumors, not the far more common follicular or papillary thyroid cancers

This is why you should focus on more than drug interactions

Type 2 diabetes and the risk of Parkinsons disease