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Global assessment of the evidence The Modified Bradford Hill Criteria was used to assess the potential relationships among various available evidence [33,34,35]

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By mimicking the effects of GLP-1, semaglutide helps regulate blood sugar levels, leading to weight loss and improved metabolic function

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Keywords: glucagon-like peptide-1 receptor agonists, obesity, major adverse cardiovascular events, obstructive sleep apnea, metabolic dysfunction-associated steatotic liver disease, chronic kidney disease INTRODUCTION Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are a class of injectable and oral medications originally developed for the treatment of type 2 diabetes (T2DM)