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Using this score, the researchers found that people with the hungry brain phenotype tended to respond poorly to liraglutide, an early-generation GLP-1 drug, but they did better on phentermine-topiramate, a non-GLP-1 drug that acts on appetite suppression in the brain but is controversial for its cardiovascular risks

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A key strength of our study is the analysis of multiple biomarkers across various doses of orforglipron, providing a robust dataset for evaluating its effects on traditional and novel CV risk biomarkers
