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A mitochondrial peptide that mimics exercise

Methods This is a cohort study combining several population-wide databases and covering a Spanish population of five million inhabitants, including all adults with obesity who initiated treatment with either GLP-1RA or SGLT-2i for type 2 diabetes from 2015 to 2021

GLP-1 receptors located in hypothalamic and brainstem centers are known to influence hunger signaling and satiety pathways, while GIP and glucagon receptor signaling contribute to nutrient sensing and metabolic feedback mechanisms