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Other studies have revealed that the expression of GLP-1R in the retina of diabetic patients is greater than that in the retina of normal people (42), and GLP-1RA can reverse diabetic retinal vascular damage through molecular mechanisms such as reducing oxidative stress and regulating vascular endothelial growth factor (43, 44)

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45 A retrospective cohort study of people with type 2 diabetes aged 18 years and older found that tirzepatide was associated with lower rates of all-cause mortality, cardiovascular events, acute kidney injury and adverse kidney events compared with GLP-1 receptor agonists