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These are worst during the first 1-2 weeks at each new dose and usually improve

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Global deprotection and cleavage of the peptides from the solid-support resin were achieved using a CEM Razor instrument via a 40-min incubation at 40 C in a mixture of 95% trifluoroacetic acid, 2.5% triisopropylsilane, and 2.5% water
