what was the first glp 1 drug GLP-1 The discovery and development of

However, these benefits can vary widely between individuals, making patient selection critical

The Core Issue: Failure to Warn Patients of Severe Risks The central argument in the GLP-1 lawsuits is that manufacturers like Novo Nordisk and Eli Lilly knew, or should have known, about the risk of severe side effects like stomach paralysis and bowel obstruction but failed to adequately warn doctors and patients

Nonetheless, the mechanistic complementarityspanning vascular delivery, metabolic signaling, and mitochondrial efficiencyoffers a biologically plausible rationale for further investigation, particularly in early disease stages where restoring energy balance may yield the greatest protective effect

Patients should ask about the recommended approach for their specific situation, which may include: Following a liquid-only diet for 24 hours before the procedure (in addition to the standard bowel preparation) Whether any medication adjustment is recommended based on individual risk factors What additional precautions the anesthesia team might take Diabetes management considerations are important for patients using GLP-1 agonists for glycemic control

He said the state has been raising awareness of the drugs among health care providers, but he declined to comment further