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However, GR also is involved in increasing blood glucose (Undesirable in diabetic patients), meaning this needs to be offset by corresponding decreases in blood glucose via GLP1R

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Microdosing seems like a middle ground between being on a full dose and going off the med cold turkey

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Effect of naltrexone-bupropion on major adverse cardiovascular events in overweight and obese patients with cardiovascular risk factors: a randomized clinical trial