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The GLP-1 market will bifurcate into a branded premium injectable tier for highest-efficacy patients and an oral generic access tier for cost-sensitive patients growing total prescription volumes while compressing per-unit average selling prices from 2030 onward

Risk factors include renal impairment, hepatic dysfunction, excessive alcohol use, and conditions causing tissue hypoxia
doi: 10.1038/nm919 15 KreigerJ-P

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Updated Side Effects/Safety Information: Warns about the serious risk of pulmonary aspiration during general anesthesia or deep sedation
