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Roches oral GLP-1 receptor agonist CT-996obtained in the $2.7 billion acquisition of Carmot Therapeuticsreduced body weight by more than 6% at four weeks versus placebo in a Phase I trial.

In classic human physiology studies, maintaining body weight at 10% below baseline was associated with a meaningful fall in energy expenditure

Read independent reviews on the GLP systems Track from Abbott on SelectScience

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Observing rs-fMRI, the functional brain connectivity in GLP-1R KO mice was significantly lower than that in the WT group (p=0.0032 for gFCD, p=0.0002 for whole-brain correlation, p<0.0001 for ALFF)