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GLP-1 receptor activation increases fluid secretion in your intestinal lining, meaning more water stays in your stool rather than being reabsorbed

For protocol design, this triple mechanism has practical implications

For fitness professionals, the goal is not to endorse or reject trends, but to interpret them clearly

This is especially true if your insurance doesnt cover the medication or if in-person visits are hard to schedule

Keywords: diabetes, metaanalysis, semaglutide, tirzepatide, weight loss The aim of this systematic review and metaanalysis was to synthesise the research on direct comparative studies between tirzepatide and semaglutide on weight loss among patients with type 2 diabetes