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A dose of 1.0 mg once weekly of semaglutide (maximum dose subsidised by the PBS) achieved a weight reduction of 4.3 kg compared with placebo over two years
Variants in the GLP1R gene (such as rs6923761) and the FTO gene (rs9939609) affect appetite signaling and metabolic rate, meaning two patients injecting identical doses may experience different weight loss trajectories
This mechanism significantly reduces the risk of hypoglycaemia (dangerously low blood sugar) compared to some other diabetes medications
