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Conclusion A population pharmacokinetic model incorporating allometric scaling was developed to simultaneously describe the PK of semaglutide in all animal species and predict its PK in humans

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Consistent reductions were seen for patients stratified by gender, age group, race and in patients with and without T2D

Conclusions GLP-1RAs had a neutral effect on the composite cardiovascular outcomes but reduced composite kidney events in the patients with advanced DKD compared with DPP-4is.

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