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Although some GLP-1RAs do not seem to naturally cross the bloodbrain barrier, they may still reach relevant brain areas via circumventricular sites and, possibly, via active transporters 4,5

Insulin resistance and Parkinson's disease: A new target for disease modification

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Novo Nordisk remains Lillys primary rival, but Lilly still holds an edge in drug development speed and manufacturing scale

Diabetologia 16 , 7585 (1979)